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49,54 In addition, the large size of mRNA and its susceptibility to degradation by nucleases result in low cellular uptake, further limiting its application

55-58 Preliminary results of the Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) study, a long-term multicenter trial on the effects of calorie-restricted diets in healthy overweight volunteers, 59 showed moderate calorie restriction can reduce several cardiovascular risk factors (LDL cholesterol, triglycerides, blood pressure, and C-reactive protein)

Given its origins in the stomach, the peptide has been found to help repair damage to the gastrointestinal tract

Animal sources include dairy products, eggs, fish, meat, and poultry

doi: 10.1038/s41569-021-00569-6 164 JangBK